In 1795, Doctor Victor Frankenstein creates a monster by putting together parts of corpses and reanimating them. Horrified by his creation, Frankenstein tries to destroy it, but the monster survives and murders his wife Elizabeth. Frankenstein chases it to the Arctic, but he succumbs to the cold weather. When the monster returns home to bury Frankenstein, it is attacked by demons, but is then rescued by two gargoyles, Ophir and Keziah. They bring it to a cathedral, where the monster meets the gargoyle queen Leonore and her second-in-command Gideon. Leonore explains that they were created by the Archangel Michael to battle demons on Earth and protect humanity. She names the creature "Adam" and invites him to join them, but he declines and chooses to depart. He is given baton-like weapons to protect himself, as more demons will come after him. The weapons allow him to "descend" demons (destroying their bodies and trapping their souls in Hell) as they have the symbol of the Gargoyle Order carved on them.
For the next two hundred years, Adam lives apart from society, killing any demon that pursues him and hiding from them. Deciding to rejoin society in the modern-day, Adam looks for and confronts a group of demons. During the fight, a police officer is killed. This causes Adam to be summoned by the gargoyles once more and they decide to imprison him as punishment. A demon Helek, who survived Adam's attack, reports to his leader, the demon prince Naberius, that Adam is alive. Naberius has disguised himself as billionaire businessman Charles Wessex and employs scientists Terra Wade and Carl Avery to conduct experiments to try to reanimate corpses. He sends a group of demons led by his most formidable warrior, Zuriel, to attack the gargoyles' cathedral and capture Adam so he can unlock the secret to resurrecting the dead.
Cast:
- Aaron Eckhart as Adam Frankenstein, a superhuman creature created by Dr. Frankenstein
- Bill Nighy as Naberius, a demon prince who poses as Charles Wessex, head of the scientific Wessex Institute
- Yvonne Strahovski as Dr. Terra Wade, a world-renowned electrophysiologist employed by Naberius to research reanimation of dead matter
- Miranda Otto as Leonore, the gargoyle queen
- Jai Courtney as Gideon, leader of the gargoyle army
- Socratis Otto as Zuriel, Naberius' most formidable warrior
- Kevin Grevioux as Dekar, a high-ranking demon who serves as the head of security at the Wessex Institute
- Caitlin Stasey as Keziah, a gargoyle
- Mahesh Jadu as Ophir, a gargoyle
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